E.S. Issachar (disambiguation)

E.S. Issachar may refer to:
 * E.S. Issachar — the E.S. in Xenosaga
 * E.S. Issachar (XS2 boss) — the boss battle in Xenosaga Episode II
 * E.S. Issachar (XS3 boss) — the boss battle in Xenosaga Episode III